YN360270 TTA-A2 953778-63-7

TTA-A2 is a potent, selective and orally activet-type voltage gated calcium channelantagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channel...

YN484058 D-JBD19 954134-42-0

D-JBD19 is a non-permeable peptide. D-JBD19 has neuroprotective effects.

YN370169 GKT136901 955272-06-7

GKT136901 is a potent, selective and orally active inhibitor ofNADPH oxidase (NOX1/4), with Kis of 160 and 165nM, respectively. GKT136901 also is a selective and direct scavenger of peroxynitrite. GKT136901 can be u...

YN320227 MK-3207 Hydrochloride 957116-20-0

MK-3207 (Hydrochloride) is a potent and orally bioavailableCGRP receptorantagonist with IC50 of 0.12nM and Kiof 0.024nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

YN320225 MK-3207 957118-49-9

MK-3207 is a potent and orally bioavailable CGRP receptor antagonist (IC50= 0.12nM; Ki value= 0.024nM); highly selective versus human AM1, AM2, CTR, and AMY3. In common with other CGRP receptor antagonists, MK...

YN372235 Afegostat D-Tartrate 957230-65-8

Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.

YN481226 TLX agonist 1 958323-31-4

TLX agonist 1 (ccrp2) is an orphan nuclear receptortailless (TLX, NR2E1)modulator (EC50=1μM;Kd= 650nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.

YN320639 A-836339 959746-77-1

A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors.in vitro: In radiolig and binding assays, A-836339 displays high affinities at CB(2) receptors an...

YN320979 Vortioxetine hydrobromide 960203-27-4

Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

YN360311 A-867744 1000279-69-5

A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of thealpha7 nicotinic acetylcholine receptors (nAChR)with an EC50 of 1.0μM.

YN320242 AS19 1000578-26-6

AS19 is a potent, selective5-HT7receptoragonist with an IC50 value of 0.83nM and a Ki of 0.6nM. AS19 is selective for5-HT7over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5Areceptors (Kis = 89.7nM, 490nM, 6.6nM and 98...

YN330659 Camstatin 1002295-95-5

Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronalnitric oxide (NO) synthase.

YN320015 CR4056 1004997-71-0

CR4056 is a selective inhibitor of human recombinant MAO-Awith an IC50 of 202.7nM. CR4056 is also a lig and ofimidazoline-2 receptor(I2R) with an IC50 of 596nM.

YN372579 CVT-10216 1005334-57-5

CVT-10216 is a highly selective, reversiblealdehyde dehydrogenase-2 (ALDH-2)inhibitor with an IC50 of 29nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3μM. CVT-10216 can reduce excessive alcohol...

YN481518 Tirasemtiv 1005491-05-3

Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium.

YN480219 RG3039 1005504-62-0

RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.

YN320491 GSK1521498 free base (hydro... 1007578-24-6

GSK1521498 free base (hydrochloride) is a potent and selectiveμ-opioid receptor (MOR)antagonist. GSK1521498 free base (hydrochloride) is being used for the treatment of disorders of compulsive consumption of food, alcohol, and ...

YN484284 NOT Receptor Modulator 1 1015231-98-7

NOT Receptor Modulator 1 is a nuclear receptor NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.

YN480236 EZ-482 1016456-76-0

EZ-482, a novel lig and ofapolipoprotein (apoE), binds to sites on apoE in the C-terminal domain withKds of 5-10μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potenti...

YN360542 GW791343 dihydrochloride 1019779-04-4

GW791343 dihydrochloride is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).