YN420074 BIP-135 941575-71-9

BIP-135 is a potent and selective ATP-competitiveGSK-3inhibitor, with IC50s of 16nM and 21nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

YN320869 Pavinetant 941690-55-7

Pavinetant (MLE-4901) is aneurokinin-3 receptor(NK3R) antagonist.

YN360695 AZD-6280 942436-93-3

AZD-6280 is a selectiveGABAA(α2/3) receptormodulator, used for treatment of generalized anxiety disorder.

YN360256 AZD7325 942437-37-8

AZD7325 is a potent and orally active partial selective PAM ofGABAAα2 and Aα3 receptor(Ki=0.3 and 1.3nM, respectively), and has less antagonistic efficacy at the Aα1  and Aα5 receptor subtypes . AZD7325 is ...

YN360255 A-803467 944261-79-4

A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.

YN380135 FPS-ZM1 945714-67-0

FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.

YN320448 GSK726701A 945721-87-9

GSK726701A is a novelprostagl and in E2 receptor 4 (EP4)partial agonist with apEC50of 7.4.

YN371231 LX-1031 945976-76-1

LX-1031 is a potent, orally availabletryptophan 5-hydroxylase (TPH)inhibitor that reduces serotonin (5-HT) synthesis peripherally.

YN360699 RN-1734 946387-07-1

RN-1734 is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and i...

YN320282 Piromelatine 946846-83-9

Piromelatine (Neu-P11) is amelatonin MT1/MT2receptor agonist,serotonin 5-HT1A/5-HT1Dagonist, and serotonin 5-HT2Bantagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic...

YN380163 (±)-Duloxetine hydrochloride 947316-47-4

(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well...

YN370035 WWL70 947669-91-2

WWL70 is a selectivealpha/beta hydrolase domain 6(ABHD6) inhibitor with an IC50 of 70nM.

YN482761 20(R)-Notoginsenoside R2 948046-15-9

20(R)-Notoginsenoside R2 is an isolated notoginsenoside fromPanax notoginseng.

YN380014 TB5 948841-07-4

TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.

YN373001 Duloxetine metabolite Para-N... 949095-98-1

Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).

YN360193 Desformylflustrabromine hydro... 951322-11-5

Desformylflustrabromine hydrochloride is a selective agonist ofα4β2neuronal nicotinic acetylcholine receptor (nAChR) with apEC50of 6.48.

YN481404 Tafamidis meglumine 951395-08-7

Tafamidis meglumine (Fx-1006A) is a potent  and  selectivetransthyretin (TTR)stabilizer, shows comparable potency  and  efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR  and  wild t...

YN480557 Neurotoxin Inhibitor 951571-70-3

Neurotoxin Inhibitor is a neurotoxin inhibitor.

YN360253 NS11394 951650-22-9

NS11394 is an orally active and unique subtype-selectiveGABAApositive allosteric receptor (PAM), with a Ki of ~0.5nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. N...

YN360068 MK-8998 953778-58-0

MK-8998 (compound 33) is a potent and selective inhibitor of the T-typecalcium channel.