YN372200 PF-04457845 1020315-31-4

PF-04457845 is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine...

YN480086 KR-33493 1021497-97-1

KR-33493 is a potent inhibitor of Fas-mediated cell death(FAF1).

YN340104 ZM39923 hydrochloride 1021868-92-7

ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR also found to be sensitive to transglutaminase.

YN371343 (S)-O-Desmethyl Venlafaxin... 1021934-03-1

(S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine ...

YN321167 Difelikefalin 1024828-77-0

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist ofkappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions suc...

YN360591 Valbenazine 1025504-45-3

Valbenazine (NBI-98854) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with theKiof 110-190nM.

YN360071 Org-26576 1026791-61-6

Org-26576 is a AMPA receptor positive allosteric modulator.

YN371234 Telotristat ethyl 1033805-22-9

Telotristat ethyl (LX1606) is a novel, orally-delivered inhibitor oftryptophan hydroxylasethat reduces serotonin production.

YN371235 Telotristat 1033805-28-5

Telotristat (LP-778902) is a potenttryptophan hydroxylaseinhibitor with anin vivoIC50 of 0.028μM.

YN360232 Tulrampator 1038984-31-4

Tulrampator (CX-1632) is an orally bioavailable positiveAMPAR(allosteric modulator ofAMPA receptor). Antidepressant.

YN320421 PF-03654746 Tosylate 1039399-17-1

PF-03654746 Tosylate is a potent and selectivehistamine H3 receptorantagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms. PF-03654746 Tosylate has potential for treatment of human c...

YN320107 JNJ-39758979 1046447-90-8

JNJ-39758979 is a selective, orally active, and high-affinityhistamine H4receptorantagonist with Kis of 12.5, 5.3, and 25nM for human, mouse, and monkey histamine H4receptor, respectively. JNJ-39758979 functionally antagoniz...

YN372192 Entacapone sodium salt 1047659-02-8

Entacapone sodium salt is a potent, reversible, peripherally acting and orally activecatechol-O-methyltransferase (COMT)inhibitor. Entacapone sodium salt inhibits COMT from rat brain, erythrocytes and liver with IC50 valu...

YN320992 MDA 19 1048973-47-2

MDA 19 is a potent and selective agonist of humancannabinoid receptor 2 (CB2), with a Ki of 43.3nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity.

YN360347 Naspm trihydrochloride 1049731-36-3

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

YN320733 SB 242084 hydrochloride 1049747-87-6

SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.

YN320439 LP-211 1052147-86-0

LP-211 is a selective and blood−brain barrier penetrant5-HT7receptoragonist, with a Ki of 0.58nM, with high selectivity over 5-HT1Areceptor (Ki, 188nM) and D2receptor (Ki, 142nM).

YN1730053 Dopamine D2 receptor antagon... 1055411-77-2

Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of thedopamine D2 receptor (D2R)with sub-mM affinity.

YN320445 NUCC-390 1060524-97-1

NUCC-390 is a novel and selective small-moleculeCXCR4 receptoragonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 promotes nerve recovery of f...

YN372831 (R)-(-)-O-Desmethyl Venlaf... 1062609-96-4

(R)-(-)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norep...