YN372272 JZL 184 1101854-58-3

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

YN320925 Bavisant dihydrochloride hydr... 1103522-80-0

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for A...

YN320686 MCOPPB triHydrochloride 1108147-88-1

MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.

YN480412 UCPH-101 1118460-77-7

UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with IC50 of 0.66 μM at EAAT1-HEK293 cells in the [³H]-D-Asp uptake assay.

YN380312 MAO-B-IN-1 1124198-17-9

MAO-B-IN-1 is an inhibitor ofmonoamine oxidase B, used for the research of neurological diseases.

YN321031 JNJ-40411813 1127498-03-6

JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of themetabotropic Glutamate 2 receptor (mGlu2R)with EC50 of 147nM.

YN350121 SR-3306 1128096-91-2

SR-3306 is a selective, potent, highly brain penetrantJNKinhibitor.

YN321305 Methylnaltrexone D3 Bromide 1131456-47-7

Methylnaltrexone D3 Bromide is the deuterium labeled Methylnaltrexone Bromide. Methylnaltrexone Bromide is aperipheral-acting opioid receptorantagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.

YN370456 VER-155008 1134156-31-2

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

YN360888 Tracazolate hydrochloride 1135210-68-2

Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator. Tracazolate hydrochloride has selectivity for β3 and potentiates α1β1γ2s (EC50=13.2μM), α1β3γ2 (EC50=1.5μM). Tracazolate hydrochloride ...

YN321244 VU0357017 hydrochloride 1135242-13-5

VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist ofM1muscarinic acetylcholine receptor, with an EC50 of 477nM. VU0357017 hydrochloride is highly selective for M1 and has no ...

YN371233 Telotristat etiprate 1137608-69-5

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.

YN360367 Mirogabalin 1138245-13-2

Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripher...

YN360198 Mirogabalin besylate 1138245-21-2

Mirogabalin besylate is a selective and orally available lig and for theα2δsubunit ofvoltage-gated calcium channels, withKds of 13.5nM, 22.7nM, 27nM, and 47.6nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, ...

YN440120 Edicotinib 1142363-52-7

Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally activecolony-stimulating factor-1 receptor (CSF-1R)inhibitor with an IC50 of 3.2nM. Edicotinib exhibits less inhibitory effects on KIT and FLT...

YN320380 TM-N1324 1144477-35-9

TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9nM/5nM in the presence of Zn2+, and 280nM/180nM in the absence of Zn2+forhuman/murine GPR39.

YN380085 J-147 1146963-51-0

J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.

YN370888 IOX4 1154097-71-8

IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines.

YN372303 D159687 1155877-97-6

D159687 is a selectivePDE4Dinhibitor.

YN320917 Tarafenacin D-tartrate 1159101-48-0

Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19nM), ~200 fold selectivity over M2 receptor.in vitro: SVT-40776 is highly selective for M(3) over M(2) receptors (...