YN360585 Basmisanil 1159600-41-5

Basmisanil is a highly selective GABAAα5 negative allosteric modulator.

YN320694 Ziprasidone amino acid 1159977-64-6

Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone exhibits potent effects of antipsychotic activity.

YN371014 ITI-214 free base 1160521-50-5

ITI-214 free base is a potent, CNS-active, orally bioavailablePDE1inhibitor (Kiof 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels....

YN320865 VU0361737 1161205-04-4

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240nM and 110nM for human and rat receptors, respectively. VU...

YN321201 TG4-155 1164462-05-8

TG4-155 is a potent, brain-permeant and selectiveEP2 receptorantagonist with a Ki of 9.9nM. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1. TG4-155 has an EP2 Schild KBof 2.4nM and display...

YN321855 M1145 1172089-00-7

M1145, a chimeric peptide, is a selectivegalanin receptor type 2 (GAL2)agonist, with a Ki of 6.55nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587nM) and a 76-fold higher affinity over GalR3 (K...

YN380006 gamma-secretase modulator 1 1172637-87-4

γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

YN371594 N-Desethyl Oxybutynin D5 h... 1173018-49-9

N-Desethyl Oxybutynin D5 hydrochloride is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-depende...

YN321188 RS102895 hydrochloride 1173022-16-6

RS102895 hydrochloride is a potentCCR2antagonist, with an IC50 of 360nM, and shows no effect on CCR1.

YN1730065 L-745870 hydrochloride 1173023-36-3

L-745870 hydrochloride is a potent, selective, brain-penetrant and orally activedopamine D4receptorantagonist with aKiof 0.43nM. L-745870 hydrochloride shows weaker affinity for D2(Kiof 960nM) and D3(Kiof 2300nM) receptors, ...

YN360175 PF-03463275 1173239-39-8

PF-03463275 is a centrally penetrant, orally available, selective, and competitiveGlyT1(glycine transporter-1) reversible inhibitor, with a Ki of 11.6nM. PF-03463275 has the potential for Schizophrenia research.

YN320188 Aticaprant 1174130-61-0

Aticaprant (CERC-501) is a potent and centrally-penetrantkappa opioidreceptor antagonist with a Ki of 0.807nM.

YN321109 Agomelatine hydrochloride 1176316-99-6

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist ofMT1 and MT2receptors with Kis of 0.1, 0.06, 0.12, and 0.27nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatin...

YN320470 Nebracetam hydrochloride 1177279-49-0

Nebracetam hydrochloride, a nootropicM1-muscarinicagonist, induces a rise of intracellular Ca2+concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i.

YN360746 Felbamate hydrate 1177501-39-1

Felbamate hydrate (W-554 hydrate) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

YN360243 CLP257 1181081-71-9

CLP257 is a selective K+-Cl−cotransporterKCC2activator with an EC50 of 616nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl−transport in neurons with...

YN360123 CLP290 1181083-81-7

CLP290 is an orally available activator of the neuron-specific K+-Cl−cotransporterKCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginin...

YN360032 ZL006 1181226-02-7

ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.

YN320876 Clozapine D8 1185053-50-2

Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Kiof 9.5nM for muscarinic M1 receptor. Clozapine is also a po...

YN320106 Tesmilifene fumarate 1185241-83-1

Tesmilifene fumarate (DPPE fumarate), an H1C receptorantagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.