YN372832 (S)-(+)-O-Desmethyl Venlaf... 1062609-99-7

(S)-(+)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norep...

YN360120 NS13001 1063331-94-1

NS13001 is a potent, selective, orally active allosteric positive modulator ofSK channels(small conductance calcium-activated potassium channels). TheEC50s are 1.8 and 0.14μM for SK2 and SK3, respectively. NS13001 holds p...

YN481005 SMND-309 1065559-56-9

SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.

YN320337 BIBP3226 TFA 1068148-47-9

BIBP3226 TFA is a potent and selective neuropeptide Y Y1(NPY Y1) and neuropeptide FF(NPFF) receptorantagonist, with Kis of 1.1, 79, and 108nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226...

YN370703 Pi-Methylimidazoleacetic aci... 1071661-55-6

Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.

YN483212 Onjisaponin Z 1078708-72-1

Onjisaponin Z is a natural product isolated fromRadix Polygalae.

YN360157 PF 04531083 1079400-07-9

PF 04531083 is a selectiveNaV1.8blocker, and used for the research of neuropathic/inflammatory pain.

YN372644 PDE-9 inhibitor 1082743-70-1

PDE-9 inhibitor is useful for neurodegenerative diseases.

YN372302 PF-04447943 1082744-20-4

PF-04447943 is a potent inhibitor of human recombinantPDE9A(IC50=12nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000nM).

YN320907 Cariprazine hydrochloride 1083076-69-0

Cariprazine, a novel second-generation antipsychotic, is a D3-preferring dopamine D2/D3 receptor partial agonist.

YN321012 Filorexant 1088991-73-4

Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3nM in binding).

YN320321 AZD-8529 1092453-15-0

AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator ofmGluR2, with an EC50 of 285nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and ...

YN320265 WAY-100635 Maleate 1092679-51-0

WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.

YN360645 Evenamide 1092977-61-1

Evenamide (NW-3509), asodium channelblocker, shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.

YN330667 HNGF6A 1093111-54-6

HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits ofROSproduction during oxidative stress. HNGF...

YN310264 SRT 2104 1093403-33-8

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

YN320864 VU0155041 1093757-42-6

VU0155041 is a potent, selective and mixed allosteric agonist/positive allosteric modulator (PAM) ofmGluR4, with EC50s of 798nM and 693nM for human and rat mGluR4, respectively. VU0155041 is a partial agonist of mGluR...

YN380142 gamma-secretase modulator 2 1093978-89-2

gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease

YN320872 JNJ-31020028 1094873-14-9

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.

YN483871 Neuronostatin-13 human 1096485-24-3

Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.