YN1730036 MRS-3777 hemioxalate 1186195-57-2

MRS-3777 hemioxalate is a selectiveadenosine A3 receptorantagonist.

YN320705 MTEP hydrochloride 1186195-60-7

MTEP hydrochloride is a potent, selective and non-competitivemGlu5antagonist with an IC50 of 5nM and a Ki of 16nM. MTEP hydrochloride produces antiparkinsonian-like effects.

YN321242 Lumateperone tosylate 1187020-80-9

Lumateperone tosylate (ITI-007 tosylate) is a 5-HT2A receptor antagonist (Ki = 0.54nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32nM), and a SERT blocker (Ki =...

YN480895 Midodrine D6 hydrochloride 1188265-43-1

Midodrine D6 hydrochloride is deuterium labeled Midodrine, which is a vasopressor/antihypotensive agent.

YN321491 Loperamide D6 hydrochloride 1189469-46-2

Loperamide D6 hydrochloride (R-18553 D6 hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is anopioid receptoragonist for the treatment of diarrhea.

YN370595 BI-409306 1189767-28-9

BI 409306 is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improve...

YN370986 N-Desmethyl Clomipramine D... 1189971-04-7

N-Desmethyl Clomipramine D3 hydrochloride is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramin...

YN1730070 Haloperidol D4 1189986-59-1

Haloperidol D4 is deuterium labeled haloperidol, and the latter is a potentdopamine D2 receptorantagonist.

YN321423 Naratriptan D3 Hydrochlorid... 1190021-64-7

Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist.

YN360115 ASP7663 1190217-35-6

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions.

YN320151 GSK1059865 1191044-58-2

GSK1059865 is a potentorexin 1 receptorantagonist.

YN320724 Brexpiprazole S-oxide 1191900-51-2

Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human5-HT1A and dopamine ...

YN280087 CZC-25146 1191911-26-8

CZC-25146 is a potent and selective LRRK2 inhibitor with IC50 of 4.76 nM and 6.87 nM for human wild type LRRK2 and G2019S LRRK2, respectively.

YN280114 CZC-54252 1191911-27-9

CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.

YN380026 LY2811376 1194044-20-6

LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 ...

YN360562 Sodium Channel inhibitor 1 1198117-23-5

Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical beha...

YN380035 Atabecestat 1200493-78-2

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally activeβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat (JNJ-54861911) is tole...

YN320545 BI-167107 1202235-68-4

BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constantKdof 84 pM.

YN480730 AV-105 1205550-99-7

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize18F-radiolabeled compounds, which are used for positron emission tomography (PE...

YN321299 Fesoterodine L-mandelate 1206695-46-6

Fesoterodine L-m and elate is an orally active, nonsubtype selective, competitivemuscarinic receptor (mAChR)antagonist with pKi values. of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-m...