Chemical structure
Cat.No.
Product Name
CAS no.
Target
AMG 579 is a potent, selective, and efficacious inhibitor ofphosphodiesterase 10A (PDE10A)with an IC50 of 0.1nM.
YN360145 Philanthotoxin 74 dihydrochlo... 1227301-51-0
Philanthotoxin 74 dihydrochloride (PhTx 74) is anAMPARantagonist; inhibitsGluR3 and GluR1with IC50s of 263 and 296nM, respectively.
MK-7622 (M1 receptor modulator) is a muscarinicM1 receptorpositive allosteric modulator.
YN320396 Balovaptan 1228088-30-9
Balovaptan (RG7314) is a highly potent and selective brain-penetrantvasopressin 1a (hV1a) receptorantagonist, with Kis of 1 and 39nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
YN321486 Chlorpromazine D6 hydrochlor... 1228182-46-4
Chlorpromazine D6 hydrochloride is the deuterium labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptor, 5-HT receptor, potassium channel, sodium channel.
YN360649 KCC2 blocker 1 1228439-36-8
KCC2 blocker 1 is an orally active and selective K+-Cl-cotransporter KCC2 blocker with an IC50 of 1μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.
YN350115 URMC-099 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activit...
AZD2423 is a potent, selective, orally bioavailable, and non-competitiveCCR2chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2nM for CCR2 Ca2+flux .
YN321071 LY2828360 1231220-79-3
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid(CB2)agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.
YN360349 DSP-2230 1233231-30-5
DSP-2230 is a selectiveNav1.7/Nav1.8blocker.
YN350045 (Z)-GW 5074 1233748-60-1
(Z)-GW 5074 is a compound which interacts with bothmHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibitsc-Raf, shows no effect on autophagy, and is effective for neur...
YN372572 BIA 10-2474 1233855-46-3
BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.
YN270087 LRRK2-IN-1 1234480-84-2
LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
YN321191 ADX88178 1235318-89-4
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4PAM) with an EC50 of 4nM for human mGluR4.
YN360382 PF-04856264 1235397-05-3
PF-04856264 is a potent and selectiveNav1.7inhibitor, with IC50s of 28, 131, 19, and 42nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-048...
YN360388 PF 05089771 1235403-62-9
PF 05089771 is a potent, orally active and selective arylsulfonamideNav1.7inhibitor, with IC50 values of 11nM, 12nM, 13nM, 171nM and 8nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05...
YN481520 P7C3-A20 1235481-90-9
P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain inju...
ABT-639 is a novel, peripherally acting, selective T-typeCa2+channel blocker.
QNZ46 is a NR2C/NR2D-selectivenMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
YN371007 Balipodect 1238697-26-1
TAK-063 is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.
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