YN320402 Brilaroxazine 1239729-06-6

Brilaroxazine (RP5603) is a potent and orally active multimodaldopamine (DA)/serotonin (5-HT)modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5nM)  and 5-HT2A ...

YN480433 LM11A-31 dihydrochloride 1243259-19-9

LM11A-31 dihydrochloride, a non-peptidep75NTR(neurotrophin receptor p75) modulator, is an orally active and potentproNGF(nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-bra...

YN320995 VU 0364439 1246086-78-1

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8nM.

YN483855 C3bot(154-182) 1246280-79-4

C3bot(154-182) is a C3 peptide enhances recovery from spinal cord injury by improving regenerative growth of descending fiber tracts. C3bot(154-182) represents a promising tool to foster axonal protection and /or repair, as well as func...

YN330045 GIBH-130 1252608-59-5

GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses theIL-1βsecretion by activated microglia (IC50=3.4nM).

YN371382 JNJ-42226314 1252765-13-1

JNJ-42226314 is a competitive, highly selective and reversible non-covalentmonoacylglycerol lipase (MAGL)inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG...

YN450065 Netarsudil hydrochloride 1253952-02-1

Netarsudil hydrochloride (AR-13324 hydrochloride) is aRho-associated protein kinas (ROCK) and norepinephrine transporter (NET)inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction.

YN371627 Mito-apocynin (C11) 1254044-38-6

Mito-apocynin (C11), an orally activemitochondria-targetedtriphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+cation. Mito-apocynin (C11) selectively targets mitochondria, and ...

YN371626 Mito-apocynin (C2) 1254044-41-1

Mito-apocynin (C2), an orally activemitochondria-targetedtriphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect.

YN360654 RQ-00203078 1254205-52-1

RQ-00203078 is a highly selective, potent and orally activeTRPM8antagonist with IC50s of 5.3nM and 8.3nM for rat and humanTRPM8channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRP...

YN373996 Neurodegenerative Disorder-T... 1254698-39-9

Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor extracted from patent WO2010128102A1, compound example 63.

YN370441 Alicapistat 1254698-46-8

Alicapistat (ABT-957) is an orally active selective inhibitor of humancalpains 1 and 2for the potential use in the treatment of Alzheimer's disease (AD).

YN321178 JNJ-42153605 1254977-87-1

JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM.

YN320534 JNJ-46281222 1254980-38-5

JNJ-46281222 is anmetabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd= 1.7nM) and a high modulatory potency (pEC50= 7.71).

YN360514 Fanapanel hydrate 1255517-78-2

Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity againstnMDA; have Ki values of 3.2nM, 100nM, and 8.5μM against quisqualate, kainate, and nMDA, respectively.

YN300032 Hydroxy-Dynasore 1256493-34-1

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively.

YN370859 THPP-1 1257051-63-0

THPP-1, a SGC chemical probe, is a potent and orally bioavailablephosphodiesterase 10A (PDE10A)inhibitor, with Ki values of 1nM and 1.3nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokine...

YN360335 (Rac)-ABT-202 dihydrochlor... 1258641-38-1

(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an agonist of nicotinic acetylcholine receptors (nAChRs) and can be used as an analgesic.

YN480400 Aripiprazole Lauroxil 1259305-29-7

Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl arip...

YN320249 JP1302 dihydrochloride 1259314-65-2

JP1302 dihydrochloride is a selective, high affinity antagonist of thealpha2C-adrenoceptor (α2C-adrenoceptor), with aKbvalue (antagonist activity) of 16nM and a Ki(binding affinity) value of 28nM.