YN440164 PLX5622 1303420-67-8

PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.

YN320137 CHPG sodium salt 1303993-73-8

CHPG sodium salt is a selectivemGluR5agonist, and attenuates SO2-induced oxidative stress and inflammation throughTSG-6/NF-κBpathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury ...

YN380033 NGP555 1304630-27-0

NGP 555 is a small-molecule modulator of γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.

YN320488 LY-2940094 1307245-86-8

LY-2940094 is a potent, selective and orally availablenociceptin receptor(NOP receptor) antagonist with high affinity (Ki=0.105nM) and antagonist potency (Kb=0.166nM). LY-2940094 reduces ethanol self-administration in animal ...

YN480441 Ogerin 1309198-71-7

Ogerin is a selectiveGPR68positive allosteric modulator, with apEC50of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220nM) at A2Areceptoor and weak antagonist activity (Ki, 736nM) at 5-HT2Breceptor. O...

YN320765 SEP-363856 hydrochloride 1310422-41-3

SEP-363856 hydrochloride（SEP-856 hydrochloride）, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride（SEP...

YN480568 PH-002 1311174-68-1

PH-002 is an inhibitor ofapolipoprotein (apo) E4intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.

YN321197 LY2812223 1311385-20-2

LY2812223 is a highly potent, functionally selectivemGlu2receptoragonist with mGlu2binding affinity for mGlu2 and mGlu3(Ki=144nM and 156nM, respectively).

YN320710 LY2979165 1311385-32-6

LY2979165 is the alanine prodrug of 2812223, a selective and potent orthostericmGlu2receptor agonist.

YN310292 YF-2 1311423-89-8

YF-2 is a highly selective, blood-brain-barrier permeablehistone acetyltransferaseactivator, acetylates H3 in the hippocampus, with EC50s of 2.75μM, 29.04μM and 49.31μM for CBP, PCAF, and GCN5, respectively, shows n...

YN310293 YF-2 hydrochloride 1312005-62-1

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeablehistone acetyltransferaseactivator, acetylates H3 in the hippocampus, with EC50s of 2.75μM, 29.04μM and 49.31μM for CBP, PCAF, and GCN5, respect...

YN360472 Ro 25-6981 Maleate 1312991-76-6

Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/N...

YN370831 7-BIA 1313403-49-4

7-BIA is areceptor-type protein tyrosine phosphatase D (PTPRD)inhibitor with an IC50 of ~1-3μM.

YN321847 Hemopressin (human, mouse) 1314035-51-2

Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist ofCB1cannabinoid receptors. Hemopressin exerts anti...

YN320322 AZD-8529 mesylate 1314217-69-0

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator ofmGluR2, with an EC50 of 285nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6,...

YN483844 PDZ1 Domain inhibitor pept... 1315378-73-4

PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR...

YN320418 NPEC-caged-LY379268 1315379-62-4

NPEC-caged-LY379268 is atype II mGluRagonist.

YN320688 Olodanrigan 1316755-16-4

Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the...

YN360584 (S)-(-)-5-Fluorowillardiine ... 1321546-70-6

(S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.

YN371541 Nordoxepin D3 hydrochloride 1331665-54-3

Nordoxepin D3 hydrochloride (Desmethyldoxepin D3 hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tri...