YN380075 LY2886721 1262036-50-9

LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.

YN360057 7-Chlorokynurenic acid sodium... 1263094-00-3

7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of theglycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor(IC50=0.56μM). 7-Chlorokynurenic acid sodium salt is als...

YN321174 S1RA hydrochloride 1265917-14-3

S1RA hydrochloride (E-52862 hydrochloride) is a potent and selective sigma-1 receptor(σ1R, Ki=17nM) antagonist, showed good selectivity against σ2R (Ki > 1000nM).in vitro: S1RA behaved as a highly selective σ1 receptor ant...

YN320428 Olorinab 1268881-20-4

Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2(CB2)agonist, with an EC50 of 6.2nM for hCB2.

YN361053 Spadin 1270083-24-3

Spadin, a natural peptide derived from a propeptide released in blood, is able to block theTREK-1(KCNK2 or K2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10nM. Spadin is an efficient anti...

YN481381 NSI-189 1270138-40-3

NSI-189, a small molecule with enhanced neurogenic activity, is a potential antidepressant for the treatment of major depressive disorder (MDD), cognitive impairment and neurodegeneration.

YN321799 Endomorphin 2 TFA 1276124-00-5

Endomorphin 2 TFA, a high affinity, highly selective agonist of theμ-opioid receptor, displays reasonable affinities for kappa3binding sites, withKivalue between 20 and 30nM.

YN360249 Topiramate D12 1279037-95-4

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is aGluR5 receptorantagonist. Topiramate produces its antiepileptic effects through enhancement ofGA...

YN371180 VP3.15 dihydrobromide 1281681-33-1

VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dualphosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3inhibitor, with IC50s of 1.59μM and 0.88μM for PDE7 and GSK-3, respectively. ...

YN280054 GSK2578215A 1285515-21-0

GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.

YN360280 VU0529331 1286725-49-2

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, ...

YN380117 Verubecestat 1286770-55-5

Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.

YN321374 Quetiapine D4 fumarate 1287376-15-1

Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.

YN371016 N-Acetyl lysyltyrosylcystein... 1287585-40-3

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor ofmyeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo...

YN320998 Rimegepant 1289023-67-1

Rimegepant is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.

YN320393 Seltorexant 1293281-49-8

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selectiveorexin-2 receptor (OX2R)antagonist (pKivalues of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrie...

YN320394 Seltorexant hydrochloride 1293284-49-7

Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selectiveOX2Rantagonist (pKivalues of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain ba...

YN480407 Padsevonil 1294000-61-5

Padsevonil (UCB0942) is a potentantiepilepticagent. Padsevonil can be used for the research of epilepsy.

YN321133 Iloperidone hydrochloride 1299470-39-5

Iloperidone hydrochloride (HP 873 hydrochloride) is aD2/5-HT2receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms.

YN320495 E1R 1301211-78-8

E1R is a positive allosteric modulator ofsigma-1 receptors(Sig1R PAM) with cognition-enhancing activity.