YN321177 PF-04995274 1331782-27-4

PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. A...

YN360557 SAR7334 hydrochloride 1333207-63-8

SAR7334 hydrochloride is a potent and specificTRPC6inhibitor, inhibiting TRPC6 currents with IC50 of 7.9nM.

YN360556 SAR7334 1333210-07-3

SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.

YN360274 PSEM 89S TFA 1336913-03-1

PSEM 89S TFA is a selective and brain penetrant agonists for the resultingion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

YN320078 YL0919 1339058-04-6

YL0919 is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptakeblocker and an effective 5-HT1A receptoragonist (Ki=0.19nM). YL0919 inhibits the uptake of [3H]-5-HT into rat cerebral cortic...

YN321017 LY2795050 1346133-08-1

LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72nM) and has the potential as a PET tracer to image KOR in vivo.

YN320747 LY2444296 1346133-11-6

LY2444296 is an orally bioavailable, high-affinity and selective short-actingkappa opioid receptor (KOPR)antagonist, with aKivalue of ∼1nM. LY2444296 exhibits anti-anxiety like effects.

YN370275 SA57 1346169-63-8

SA57 is a potent, selectiveFAAHinhibitor with IC50s of 3.2nM and 1.9nM formouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolasesMAGL(IC50s of 410nM and 1.4μM formouse and human MAG...

YN360128 ML218 1346233-68-8

ML218 is a potent, selective and orally activeT-type Ca2+channels (Cav3.1, Cav3.2, Cav3.3)inhibitor with IC50s of 310nM and 270nM forCav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleu...

YN380077 Rivastigmine carbamate impuri... 1346242-31-6

Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and a...

YN372561 JNJ-42165279 1346528-50-4

JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.

YN450140 Nefopam D3 1346747-15-6

Nefopam D3 (Fenazoxine D3) is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells.

YN280058 HG-10-102-01 1351758-81-0

HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3nM) and the G2019S mutant(IC50=3.2nM) IC50 Value: 23.3nM (WT LRRK2); 3.2nM (LRRK2 G2019S)

YN280104 GNE-7915 1351761-44-8

GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and Ki of 9 nM and 1 nM, respectively.

YN371654 CMS-121 1353224-53-9

CMS-121 is a quinolone derivative and an orally activeacetyl-CoA carboxylase 1 (ACC1)inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage withEC50values of 7nM and 200nM, respectively. CMS-1...

YN321352 Naloxegol oxalate 1354744-91-4

Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is aμ-opioid-receptorantagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induce...

YN360470 Nav1.7 inhibitor 1355631-24-1

Nav1.7 inhibitor (compound II), a sulfonamide, is a potentNav1.7inhibitor. Nav1.7 inhibitor has the potential for a wide range of disorders, particularly pain.

YN480363 RO5263397 1357266-05-7

RO5263397 is a potent, selective, and orally availableTAAR1agonist, with EC50s of 17 and 35nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepr...

YN380051 Vafidemstat 1357362-02-7

Vafidemstat (ORY-2001) is a dual lysine-specific histone demethylase (LSD1)/MAO-Binhibitor.

YN480169 FTBMT 1358575-02-6

FTBMT is a selectiveGPR52agonist with an EC50 of 75nM. FTBMT has antipsychotic and procognitive properties.