YN321230 JNJ-46778212 1363281-27-9

JNJ-46778212 (VU 0409551) is anmGlu5positive allosteric modulator with an EC50 of 260nM.

YN321085 Lemborexant 1369764-02-2

Lemborexant (E-2006) is a reversible, competitive and orally active dual antagonist of theorexin OX1 and OX2 receptorswith IC50 values of 6.1nM and 2.6nM, respectively. Lemborexant can be treated insomnia.

YN320806 IPSU 1373765-19-5

IPSU is a selective, orally available and brain penetrantOX2Rantagonist with a pKi of 7.85.

YN320579 Ubrogepant 1374248-77-7

Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.

YN330228 Sulfo-ara-F-NMN 1374663-29-2

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activatingSARM1but inhibitingCD38(IC50around 10μM). Sulfo-ara-F-NMN induces intracellular cyclic AD...

YN280086 GNE0877 1374828-69-9

GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM.

YN290452 ACY-775 1375466-18-4

ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5  nM.

YN320567 BMS-984923 1375752-78-5

BMS-984923, a potentmGluR5silent allosteric modulator (SAM), with exquisite binding affinity (Ki= 0.6nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interactio...

YN320700 LY3020371 1377615-75-2

LY3020371 is a potent and selective antagonist ofglutamate (mGlu) 2/3 receptor, with Kis of 5.26 and 2.50nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression.

YN320509 LY3027788 1377615-76-3

LY3027788, a diester analog of LY3020371 which is anmGlu2/3 receptorantagonist, is a potent and orally active prodrug of LY3020371. LY3027788 has antidepressant efficacy.

YN480673 SR10067 1380548-02-6

SR10067 is a potent, selective and brain penetrantRev-Erbα/βagonist, with IC50 values are 160 and 170nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity.

YN320339 CYM 9484 1383478-94-1

CYM 9484 is a selective and highly potentneuropeptide Y (NPY) Y2 receptorantagonist with an IC50 value of 19nM.

YN321308 Alvimopan monohydrate 1383577-62-5

Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversibleμ-opioid receptorantagonist, with an IC50 of 1.7nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (Ki=0.47nM) ove...

YN420137 Vps34-PIK-III 1383716-40-2

PIK-III, which is a selective inhibitor of ?VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0....

YN380011 Lanabecestat 1383982-64-6

Lanabecestat（AZD3293, LY3314814）is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki?of?0.4 nM.

YN380012 (1α,1'S,4β)-Lanabecestat 1384082-96-5

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is aBeta site APP Cleaving Enzymel (BACE1)inhibitor extracted from patent WO2012087237A1, compound 20a, hasIC50s of 2.2nM (TR-FRET assay) and 0.28nM (sAPPp...

YN1730059 ML417 1386162-69-1

ML417 is a selective and brain penetrantD3 dopamine receptor (D3R)agonist, with an EC50 of 38nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with...

YN380036 Elenbecestat 1388651-30-6

Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrantBACE-1inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.

YN320779 Loperamide phenyl 1391052-94-0

Loperamide phenyl is an impurity of Loperamide (HY-B0418A). Loperamide is anopioid receptoragonist.

YN360729 Vigabatrin hydrochloride 1391054-02-6

Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminaseinhibitor. Vigabatrin hydrochloride is an antiepileptic agen...