YN360241 VU0463271 1391737-01-1

VU0463271 is a potentKCC2antagonist, with an IC50 of 61nM.

YN380249 Picfeltarraegenin X 1391826-61-1

Picfeltarraenin X, a triterpenoid isolated fromPicria fel-terraeLour, is anAChEinhibitor.

YN360814 Tetrabenazine D6 1392826-25-3

Tetrabenazine D6 is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

YN370504 PF-05180999 1394033-54-5

PF-05180999 is aphosphodiesterase 2A (PDE2A)inhibitor, with an IC50 of 1.6nM.

YN321068 Auglurant 1396337-04-4

Auglurant (VU0424238) is a novel and selectivemGlu5antagonist with an IC50 value of 11nM (rat) and an IC50 value of 14nM (human). Auglurant (VU0424238) has an acceptable CNS penetration.

YN320631 Piribedil D8 1398044-45-5

Piribedil D8 (ET-495 D8) is the deuterium labeled Piribedil, which is an antiparkinsonian agent.

YN380176 Clomipramine D3 hydrochlorid... 1398065-86-5

Clomipramine D3 hydrochloride is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Kiof 0.14...

YN320498 (2R,3R)-E1R 1400888-63-2

(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is asigma-1 receptorpositive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

YN321072 Oliceridine 1401028-24-7

Oliceridine (TRV130) is a novelmu opioid receptor (MOR)agonist that preferentially activates G-protein versus β-arrestin signaling pathways coupled to MORs.

YN321074 Oliceridine Racemate 1401028-25-8

Oliceridine Racemate (TRV130 Racemate) is the racemate of Oliceridine. Oliceridine is a novelmu opioid receptor (MOR)agonist that preferentially activates G-protein versus β-arrestin signaling pathways coupled to MORs.

YN321073 Oliceridine hydrochloride 1401031-39-7

Oliceridine hydrochloride (TRV130 hydrochloride) is a G protein biasedμ opioid receptoragonist with anpEC50of 8.1.

YN320709 BAN ORL 24 1401463-54-4

BAN ORL 24 is a potent and selective NOP receptor antagonist. (IC50 values are 0.27, 2500, 6700 and > 10000nM for NOP, κ-, μ- and δ-receptors respectively). BAN ORL 24 inhibits nociceptin-induced stimulation o...

YN440367 Dihexa 1401708-83-5

Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds tohepatocyte growth factor (HGF)with high affinity (Kd=65 pM) and potentiates its activity at its receptor,...

YN290214 PE859 1402727-29-0

PE859 is a potent inhibitor of bothtau and Aβaggregation with IC50 values of 0.66 and 1.2μM, respectively.

YN360705 Ca2+ channel agonist 1 1402821-24-2

Ca2+channel agonist 1 is an agonist ofN-type Ca2+channel and an inhibitor of CDK2, with EC50s of 14.23μM and 3.34μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

YN360338 GV-58 1402821-41-3

GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. In comparison with the parent molecule, (R)-rosc...

YN321067 Asenapine hydrochloride 1412458-61-7

Asenapine hydrochloride, an antipsychotic, is a5-HT(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4)receptor antagonist with Ki values of 0.03-4.0nM for 5-HT and 1.3, 0.42, 1.1nM for Dopamine receptor, respecti...

YN320057 VU0364770 hydrochloride 1414842-70-8

VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) ofmGlu4. VU0346770 hydrochloride exhibitsEC50s of 290nM and 1.1μM atrat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydro...

YN450121 Verosudil 1414854-42-4

Verosudil (AR-12286) is a potent, selectiveRho-kinase (ROCK)inhibitor with Kis of 2 and 2nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outf...

YN480102 T807 1415379-56-4

T807 a noveltaupositron emission tomography (PET) tracer.