YN1730074 ST-836 hydrochloride 1415564-68-9

ST-836 hydrochloride (compound 34) is a potentdopamine receptorlig and with Ki values of 4.5nM, 132nM for D3 and D2, respectively. ST-836 hydrochloride has the potential for Parkinson’s disease.

YN370226 PF-05085727 1415637-72-7

PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependentPDE2A(IC50=2nM). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.

YN321097 TG6-10-1 1415716-58-3

TG6-10-1 is anEP2antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.

YN370974 JW 642 1416133-89-5

JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. IC50 value: 7.6/14/3.7nM(mouse...

YN360279 AMG 333 1416799-28-4

AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.

YN360119 Apimostinel 1421866-48-9

Apimostinel (NRX-1074; AGN-241660) is an orally activeNMDA receptorpartial agonist.

YN420174 IM156 1422365-94-3

IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin (HY-B0627), is a potentAMPKactivator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156...

YN320497 (2S,3S)-E1R 1424832-57-4

(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is asigma-1 receptorpositive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

YN320496 (2R,3S)-E1R 1424832-60-9

(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is asigma-1 receptorpositive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

YN420077 EHT 5372 1425945-60-3

EHT 5372 is a strong inhibitor ofDYRK’sfamily kinases, with IC50s of 0.22, 0.28nM for DYRK1A and DYRK1B, respectively.

YN374000 PDE2/PDE10-IN-1 1426833-08-0

PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10inhibitor with IC50s of 29 and 480nM, respectively.

YN360084 JNJ-47965567 1428327-31-4

JNJ-47965567 is a centrally permeable, high-affinity, selectiveP2X7antagonist, withpKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CN...

YN320644 CB1-IN-1 1429239-98-4

CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3nM and 21nM for CB1R (EC50 = 3nM) and CB2R, respectively.

YN360465 (S)-UFR2709 1431628-22-6

(S)-UFR2709 is a competitivenAChRantagonist  and displays higher affinity for α4β2nAChRs than for α7nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring...

YN320416 ADX71743 1431641-29-0

ADX71743 is a highly selective, noncompetitive and brain-penetrantmetabotropic glutamate receptor 7negative allosteric modulator (mGlu7 NAM). ADX71743 has anxiolytic-like activity.

YN380146 gamma-secretase modulator 3 1431697-84-5

gamma-secretase modulator 3 is a gamma-secretase modulator.

YN360354 Nicardipine D3 hydrochloride 1432061-50-1

Nicardipine D3 hydrochloride (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC50 of 1μM for blocking cardiac calcium channels. Nicardipine hydrochlor...

YN320729 mGluR2 antagonist 1 1432728-49-8

mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class ofmGluR2negative allosteric modulator (IC50 of 9nM) with excellent brain permeability.

YN1730049 UCSF924 1434515-70-4

UCSF924 is a potent and specificdopamine D4 receptor (DRD4)partial agonist with aEC50of 4.2nM. UCSF924 has a high-affinity with aKivalue of 3nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L...

YN380162 Duloxetine D3 hydrochloride 1435727-97-1

Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Kiof 4.6nM, used for treatme...