YN280032 PFE-360 1527475-61-1

PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally activeleucine-rich repeat kinase 2 (LRRK2)inhibitor with a mean IC50 of 2.3nM in vivo.

YN320646 AF38469 1531634-31-7

AF38469 is a selective, orally bioavailableSortilininhibitor with an IC50 value of 330nM.

YN280039 GNE-9605 1536200-31-3

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.

YN480026 GSK-2881078 1539314-06-1

GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.

YN370857 SBFI-26 1541207-06-0

SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteinsFABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti...

YN320655 LML134 1542135-76-1

LML134 (compound 18b) is an orally active and high selectiveHistamine 3 receptor (H3R)inverse agonist with Kis of 0.3nM and 12nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R...

YN481837 Taltirelin acetate 1549593-23-8

Taltirelin acetate (TA-0910 acetate) is a superagonist atthyrotropin-releasing hormone receptor (TRH-R)with an IC50 of 910nM and EC50of 36nM for stimulating an increase in cytosolic Ca2+concentration (Ca2+release).

YN360304 Cav 2.2 blocker 1 1567335-29-8

Cav 2.2 blocker 1 (compound 9) is aN-type calcium channel (Cav 2.2)blocker for the treatment of pain, with an IC50 of 1nM.

YN270178 ISRIB (trans-isomer) 1597403-47-8

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.

YN310156 T-448 free base 1597426-52-2

T-448 free base is a specific, orally active and irreversible inhibitor oflysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22nM. T-448 free base enhances H3K4 methylation in primary cultured rat neuro...

YN310157 T-448 1597426-53-3

T-448 is a specific, orally active and irreversible inhibitor oflysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22nM. T-448 enhances H3K4 methylation in primary cultured rat neurons.

YN361035 Huwentoxin XVI 1600543-88-1

Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalianN-type calcium channel(IC50 of ~60nM) antagonist from Chinese tarantulaOrnithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type ca...

YN370858 BPN14770 1606974-33-7

BPN14770 is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

YN480003 (1R,2R)-2-PCCA(hydrochlo... 1609563-71-4

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptoragonist, with an EC50 of 3nM in cell-free assay, and 603nM in cell assay.

YN360228 LY3130481 1610802-47-5

LY3130481 is anAMPA receptorantagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65nM.

YN360396 (E)-GABAB receptor antag... 1611483-29-4

(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator ofGABAB (γ-Aminobutyric acid) receptors. (E)-GAB...

YN320122 BAR502 1612191-86-2

BAR502 is a dualFXR and GPBAR1agonist with IC50 values of 2μM and 0.4μM, respectively.

YN321540 Propranolol D7 hydrochloride 1613439-56-7

Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselectiveβ-adrenergic receptor (βAR)antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8n...

YN480240 Monomethyl fumarate D3 1616345-41-5

Monomethyl fumarate D3 is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate.

YN350086 DLK-IN-1 1620574-24-4

DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase(DLK, MAP3K12), with a Ki of 3nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at co...