YN360588 Rapastinel Trifluoroacetate 1435786-04-1

Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptormodulator with glycine-site partial agonist properties. Rapastinel Trifluoroacetate has the potential for major depressive disorder treatment.

YN370856 MJN110 1438416-21-7

MJN110 is an orally active and selectivemonoacylglycerol lipase (MAGL)inhibitor with IC50s of 9.1nM and 2.1nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively. MJN110 produces opioid-sparing effects and ...

YN320400 Opiranserin 1441000-45-8

Opiranserin, a non-opioid and non-NSAID analgesic c and idate, is a dual antagonist ofglycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3μM, respectively. Opiranserin shows a...

YN360247 ML 297 1443246-62-5

ML 297 (VU 0456810) is a potent and selectiveGIRK1/2activator, with an EC50 of 0.16μM. ML 297 is potential for the treatment of epilepsy.

YN360307 ML67-33 1443290-89-8

ML67-33 is a selective activator of temperature- and mechano-sensitiveK2Pchannels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3μM and 9.7μM in cell-free and HEK293 cells, respectivel...

YN360046 AM-2099 1443373-17-8

AM-2099 is a potent and selective inhibitor of voltage-gated sodium channelNav1.7with an IC50 of 0.16μM for human Nav1.7.

YN320035 Lu AF21934 1445605-23-1

Lu AF21934 is a selective and brain-penetrantm Glu4receptor positive allosteric modulator with an EC50 of 500nM for mGlu4 receptor.

YN370860 ABX-1431 1446817-84-0

ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.

YN321070 ML314 1448895-09-7

ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.

YN360287 PF-06305591 1449473-97-5

PF-06305591 is a potent and highly selective voltage gated sodium channelNaV1.8blocker, with an IC50 of 15nM. An excellent preclinicalin vitroADME and safety profile.

YN360317 Tipepidine hydrochloride 1449686-84-3

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2receptor-mediatedGIRK currents (IDA(GIRK))with an IC50 of 7.0μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydroch...

YN360409 DS-1971a 1450595-86-4

DS-1971a is a potent, selective, and orally activeNaV1.7inhibitor, with IC50s of 22.8 and 59.4nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

YN320450 VU0467154 1451993-15-9

VU0467154 is a positive allosteric modulator of theM4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh withpEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

YN480677 LP-935509 1454555-29-3

LP-935509 is a selective, ATP-competitive and brain-penetrant inhibitor ofadapter protein-2 associated kinase 1 (AAK1)with an IC50 and a Ki of 3.3nM and 0.9nM, respectively. LP-935509 is also a potent inhibitor of BIK...

YN480723 LP-922761 1454808-95-7

LP-922761 is a potent, selective and orally activeadapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8nM and 7.6nM in enzyme and cell assays, respectively. LP-922761 also inhibitsBMP-2-inducible prot...

YN370823 KT185 1472640-86-0

KT185 is an orally-bioavailable, brain-penetrant and selectiveABHD6inhibitor, with anIC500.21nM in Neuro2A cells.

YN360285 GDC-0276 1494581-70-2

GDC-0276 is a potent, selective, reversible and orally activeNaV1.7inhibitor with an IC50 value of 0.4nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment...

YN320401 Nemorexant 1505484-82-1

Nemorexant (ACT-541468) is a potentorexin receptorantagonist extracted from patent WO2015083094A1, compound example 7, hasIC50s of 2nM and 3nM forOx1receptor and Ox2receptor, respectively.

YN370423 JJKK 048 1515855-97-6

JJKK 048 is an ultrapotent and highly selective inhibitor ofMonoacylglycerol lipase(MAGL).

YN280042 PF-06447475 1527473-33-1

PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.