YN370898 KY-226 1621673-53-7

KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by ...

YN320595 NTRC-824 1623002-61-8

NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptideneurotensin receptor type 2 (NTS2)antagonist with an IC50 of 38nM and a Ki of 202nM. NTRC-824 is >150-fold selectivity forNTS2over NTS1 (...

YN280003 MLi-2 1627091-47-7

MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 ...

YN360298 JNJ-54175446 1627902-21-9

JNJ-54175446 is a potent and selective brain penetrantP2X7 receptorantagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

YN360275 HC-070 1628291-95-1

HC-070 is an antagonist ofTRPC4/TRPC5, with IC50s of 9.3nM and 46nM for hTRPC5 and hTRPC4 in cells, respectively.

YN350091 MW-150 1628502-91-9

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor ofp38α MAPKwith a Ki of 101nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK...

YN360124 Zuranolone 1632051-40-1

Zuranolone is an orally active and potent neuroactive steroid positive allosteric modulator ofGABAAreceptor, with EC50s of 296 and 163nM forα1β2γ2 and α4β3δ GABAAreceptors, respectively.

YN320953 Mavoglurant racemate 1636881-61-2

Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.

YN1730058 ONC206 1638178-87-6

ONC206 is a selective antagonist of dopamine D2-like receptor (DRD2) and has broad-spectrum anti-tumor activity.

YN1730051 LY3154207 1638667-79-4

LY3154207 is a potent, subtype selective, and orally availablehuman dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3nM).

YN320611 Sigma-1 receptor antagonist 2 1639220-15-7

Sigma-1 receptor antagonist 2 is a potent and selectivesigma 1 receptor(σ1 R) antagonist with Kis of 3.88 and 1288nM for σ1 and σ2 receptor, respectively.

YN320612 Sigma-1 receptor antagonist 3 1639220-17-9

Sigma-1 receptor antagonist 3 (compound135) is a potent and selectiveSigma-1 (σ1) receptorantagonist with a Ki of 1.14nM. Sigma-1 receptor antagonist 3 inhibitsHuman Ether-a-go-go-Related Gene (hERG)with an IC50 of 1.54μM...

YN320613 Sigma-1 receptor antagonist 1 1639220-19-1

Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selectivesigma-1 receptor (σ1R)antagonist, with a high binding affinity to σ1R receptor (Ki= 1.06nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activ...

YN371015 ITI-214 1642303-38-5

ITI-214 is a potent, CNS-active, orally bioavailablePDE1inhibitor (Kiof 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-21...

YN330054 SAFit1 1643125-32-9

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3nM.

YN1730042 (Rac)-Tavapadon 1643462-64-9

(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatecholdopamine D1 receptoragonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruit...

YN280017 Autophinib 1644443-47-9

Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitr...

YN480443 ML382 1646499-97-9

ML382 is a potent and selectiveMRGPRX1(Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190nM.

YN290538 [pThr3]-CDK5 Substrate 1670273-47-8

[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosp...

YN310106 EML 425 1675821-32-5

EML425 is a potent and selective CREB binding protein (CBP)/p300inhibitor with IC50s of 2.9 and 1.1μM, respectively.