YN484150 β-Amyloid (1-40), FAM-lab... 1678416-08-4

β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm).

YN380069 TrkA-IN-1 1680179-43-4

TrkA-IN-1 is a potent and selectiveTropomyosin-related kinase A (TrkA)inhibitor with an IC50 of 99nM in a cell-based assay. TrkA-IN-1 has analgesic activity.

YN280095 JH-II-127 1700693-08-8

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6nM, 2.2nM ,47.7nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.

YN420151 GSK-3β inhibitor 2 1702428-31-6

GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally activeGSK-3βinhibitor with an IC50 of 1.1nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's...

YN360117 CM-4620 1713240-67-5

CM-4620 is acalcium-release activated calcium-channel (CRAC channel)inhibitor, with IC50s of 119nM and 895nM forOrai1/STIM1 and Orai2/STIM1 channels, respectively.

YN360029 LY2365109 hydrochloride 1779796-27-8

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8nM for glycine uptake in cells over-expressing hGlyT1a.

YN320235 SB 243213 dihydrochloride 1780372-25-9

SB 243213 dihydrochloride is an orally active, selective and high-affinity5-HT2Creceptorantagonist with a pKi of 9.37 and apKbof 9.8 for human 5-HT2Creceptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivi...

YN310095 Ro 32-0432 hydrochloride 1781828-85-0

Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally activePKCinhibitor. TheIC50 values of Ro 32-0432 hydrochloride forPKCα,PKCβI,PKCβII,PKCγ and PKCεare 9.3nM, 28nM, 30nM, 36.5n...

YN320330 SNAP 94847 hydrochloride 1781934-47-1

SNAP 94847 hydrochloride is a novel, high affinity selectivemelanin-concentrating hormonereceptor1 (MCHR1)antagonist with (Ki= 2.2nM,Kd=530 pM), it displays >80-fold and >500-fold selectivity overMCHα1A and MCHD2recep...

YN330177 AR-C102222 hydrochloride 1781934-50-6

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selectiveinducible nitric oxide synthase (iNOS)inhibitor, with an IC50 of 37nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory a...

YN480426 KHS101 hydrochloride 1784282-12-7

KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.

YN360655 CP-465022 hydrochloride 1785666-59-2

CP-465022 hydrochloride is a potent, and selective noncompetitiveAMPA receptorantagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25nM in rat cortical neurons. CP-465022 pro...

YN270366 (R)​-​CR8 trihydrochlorid... 1786438-30-9

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potentCDK1/2/5/7/9inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09μM), CDK2/cyclin A (0.072μM), CDK2/cyclin E...

YN320403 Masupirdine mesylate 1791396-46-7

Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant5-HT6 receptorantagonist (Kiof 2.04nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high ...

YN320370 PD 144418 oxalate 1794760-28-3

PD 144418 oxalate is a highly affinity, potent and selectivesigma 1 (σ1) receptorlig and (Kivalues of 0.08nM and 1377nM forσ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, i...

YN321214 Orexin 2 Receptor Agonist 1796565-52-0

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.

YN380050 Trk-IN-4 1799788-94-5

Trk-IN-4 (PF-6683324 isomer) is a potentpan-Trkinhibitor in cell-based assays with IC50s of 1.9nM, 2.6nM and 1.1nM forTrkA,TrkB and TrkC, respectively. Anti-hyperalgesic effect.

YN321249 JNJ-63533054 1802326-66-4

JNJ-63533054 is a potent, selective and orally activeGPR139agonist with an EC50 of 16nM forhuman GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ...

YN280023 LRRK2 inhibitor 1 1802525-61-6

LRRK2 inhibitor 1 is a potent, selective and oralLRRK2inhibitor with an pIC50 of 6.8nM.

YN320444 Sigma-2 receptor antagonist 1 1802632-22-9

Sigma-2 receptor antagonist 1 is asigma-2 (σ-2) receptorantagonist.