YN320675 Pimozide D4 1803193-57-8

Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is adopamine receptorantagonist, with Kis of 1.4nM, 2.5nM and 588nM fordopamine D2,D3 and D1 receptors, respectively, and also has affinity atα1-adrenoceptor...

YN360389 EN6 1808714-73-9

EN6 is a small-molecule in vivo activator ofautophagythat covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal thevacuolar H+ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATP...

YN280030 P62-mediated mitophagy induce... 1809031-84-2

P62-mediated mitophagy inducer is amitophagyregulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.

YN320383 VU0650786 1809085-30-0

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator ofmetabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392nM. VU0650786 has antidepressant and anxiolytic activity in rodent...

YN371605 EC5026 1809885-32-2

EC5026 (BPN-19186) is a first-in-class, non-opioid and orally activesoluble Epoxide Hydrolase (sEH)inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain.

YN380047 PF-06751979 1818339-66-0

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3nM in BACE1 binding assay.

YN320565 TAK-071 1820812-16-5

TAK-071 is a novel, potent and highly selectivemuscarinic acetylcholine receptor 1 (M1R)positive allosteric modulator.EC50of TAK-071 M1R agonist activities is 520nM.

YN290089 Risdiplam 1825352-65-5

Risdiplam (RG7916) is an orally administered, centrally and peripherally distributedSMN2pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

YN330658 Tat-NR2B9c TFA 1834571-04-8

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, withEC50values of 6.7nM and 670nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA dis...

YN360282 ACT-709478 1838651-58-3

ACT-709478 is a potent, selective, orally active, and brain penetratingT-type calcium channelblocker. ACT-709478 is used in the research of generalized epilepsies.

YN480103 MK-6240 1841078-87-2

MK-6240 is a tau positron emission tomography (PET) tracer forneurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs.

YN320617 SBI-553 1849603-72-0

SBI-553 is a potent and brain penetrantNTR1allosteric modulator, with an EC50 of 0.34μM.

YN360205 GNE-0723 1883518-31-7

GNE-0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21nM for GluN2A, 7.4 and 6.2μM for GluN2C and GluN2D, respectively.

YN360203 AM-0902 1883711-97-4

AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131nM forrTRPA1 and hTRPA1, respectively.

YN350109 Salicortin 1887055-63-1

Salicortin, a phenolic glycoside, has been isolated from many plants such asPopulus and Salixspecies. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulatingJNK and NF-κB/NFATc1signaling pathwa...

YN370167 PDE1-IN-2 1904611-63-7

PDE1-IN-2 is an inhibitor ofPDE1extracted from patent WO2016/55618 A1, example 31; hasIC50 values of 6, 140 and 164nM for PDE1C, PDE1B and PDE1A, respectvely.

YN1730032 Foscarbidopa 1907685-81-7

Foscarbidopa (Carbidopa 4′-monophosphate) is a prodrug of Carbidopa, acts as adopamine receptoragonist.

YN480218 BT-11 1912399-75-7

BT-11 is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).

YN380055 BPN-15606 1914989-49-3

BPN-15606 is a highly potent, orally activeγ-secretasemodulator (GSM), attenuates the production ofAβ42 and Aβ40by SHSY5Y neuroblastoma cells with IC50 values of 7nM and 17nM, respectively. BPN-15606 lowers Aβ42 ...

YN380084 Aβ42-IN-2 1914989-80-2

Aβ42-IN-2 is aγ-secretasemodulators extracted from patent WO2016070107, compound example 36. Aβ42-IN-2 has an IC50 of 6.5nM for Αβ42. Aβ42-IN-2 can be used for the research of a disorder associated with aberrant A3 pep...