YN310333 PF-CBP1 hydrochloride 2070014-93-4

PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.

YN280105 GNE-7915 tosylate 2070015-00-6

GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9nM.

YN360394 ML204 hydrochloride 2070015-10-8

ML204 hydrochloride is a novel, potent, selectiveTRPC4/TRPC5channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, o...

YN480903 Mebeverine alcohol D5 2070015-15-3

Mebeverine alcohol D5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.

YN480902 Mebeverine acid D5 2070015-30-2

Mebeverine acid D5 is the deuterium labeled Mebeverine Acid; Mebeverine Acid is a metabolite of Mebeverine, that is an antispasmodic.

YN360392 VBIT-4 2086257-77-2

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17μM. VBIT-4, as anapoptosisinhibitor, can be used for therapeutic purposes in apoptosis-associated disorders...

YN360439 VBIT-12 2089227-65-4

VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.

YN320126 (Rac)-VU 6008667 2092917-63-8

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8μM,pIC50= 5.75), has high CNS penetration.

YN320125 VU 6008667 2092923-21-0

VU 6008667 is a selective negative allosteric modulator ofM5 NAMwith IC50s of 1.2μM and 1.6μM for human M5 and rat M5, respectively. High CNS penetration.

YN480111 (R)-VU 6008667 2097818-14-7

(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC50>10μM).

YN484161 RAD16-I hydrochloride 2100275-49-6

RAD16-I hydrochloride, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. RAD16-I is a well-studied ionic co...

YN280040 BL-918 2101517-69-3

BL-918 is an orally activeUNC-51-like kinase 1 (ULK1)activator with an EC50 of 24.14nM. BL-918 exerts its cytoprotectiveautophagiceffect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) t...

YN370288 IPN-60090 dihydrochloride 2102101-72-2

IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor ofGLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS...

YN1730038 JNJ-37822681 dihydrochlorid... 2108806-02-4

JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2receptor antagonist with a moderate binding affinity for the dopamine D2Lreceptor (Ki=158nM), which has potential for the treatment o...

YN380048 Glutaminyl Cyclase Inhibito... 2110449-60-8

Glutaminyl Cyclase Inhibitor 1 is aglutaminyl cyclaseinhibitor with an IC50 of 0.5μM.

YN321350 Flibanserin D4 2122830-90-2

Flibanserin D4 is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1nM) and an antagonist of 5-HT2A (49nM).

YN360370 VU0810464 2126040-21-7

VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165nM) and GIRK1/4 (EC50=720nM) chann...

YN290149 SW-100 2126744-35-0

SW-100, a selectivehistone deacetylase 6 (HDAC6)inhibitor with an IC50 of 2.3nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cros...

YN320381 Foliglurax monohydrochloride 2133294-96-7

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4PAM) , with an EC50 of 79nM. Antiparkinsonian...

YN320438 SR17018 2134602-45-0

SR17018 is anmu-opioid-receptor (MOR)agonist, binding with GTPγS, with an EC50 of 97nM.