YN360048 (-)-Bicuculline methobromide 73604-30-5

(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+channels in various types of neuro...

YN320198 Lidanserin 73725-85-6

Lidanserin (ZK-33839) acts as a5-HT2A and α1-adrenergic receptorantagonist.

YN320289 Ketanserin 74050-98-9

Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.

YN1730021 SKF-82958 hydrobromide 74115-01-8

SKF-82958 ((±)-SKF 82958) hydrobromide is adopamine D1 receptorfull agonist (K0.5=4nM), displays selective for D1 over D2 receptors (K0.5=73nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cycl...

YN330031 3-Bromo-7-nitroindazole 74209-34-0

3-Bromo-7-nitroindazole is a more potent and selective inhibitor ofneuronal nitric oxide synthase (nNOS)than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxi...

YN321896 Sauvagine 74434-59-6

Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is amammalian CRFagonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, t...

YN320342 Methiothepin mesylate 74611-28-2

Methiothepin mesylate is a potent and non-selective5-HT2receptorantagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and...

YN370086 (E)-10-Hydroxynortriptyline ... 74853-74-0

(E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

YN320090 5-Carboxamidotryptamine malea... 74885-72-6

5-Carboxamidotryptamine maleate (5-CT maleate) is a potent5-HT1A,5-HT1B,5-HT1D,5-HT5 and 5-HT7receptorsagonist .

YN321175 PRE-084 hydrochloride 75136-54-8

PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44nM in the sigma receptor assay. IC50 value: 44nM in vitro: PRE-084 has an IC50 of more than 100,000nM for PCP receptors and an IC50 high...

YN321469 Moxonidine 75438-57-2

Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

YN360563 CGP37157 75450-34-9

CGP37157 is a potent, selective inhibitor ofNa+/Ca2+exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8μM.

YN360601 Flupirtine Maleate 75507-68-5

Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

YN321470 Moxonidine hydrochloride 75536-04-8

Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

YN320241 (Rac)-WAY-161503 75704-24-4

(Rac)-WAY-161503 is a potent, selective, highly affinity5-HT2Creceptoragonist with a Ki of 4nM and an EC50of 12nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2Cthan 5-HT2A and 5-HT2Breceptors. (Rac)-WAY...

YN321990 Dynorphin A (1-8) 75790-53-3

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural lig and of thekappareceptor. The binding of 3H-Bremazocine to the purified kappa receptor is i...

YN370769 4-Hydroxynonenal 75899-68-2

4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor ofacetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modu...

YN480823 (R)-Nicardipine 76093-35-1

(R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is acalcium channelblocker with an IC50 of 1μM for blocking cardiac calcium channels. Nicardipine acts as an agent for ...

YN480822 (S)-Nicardipine 76093-36-2

(S)-Nicardipine ((S)-YC-93 free base) is the less active S enantiomer of Nicardipine. Nicardipine is acalcium channelblocker with an IC50 of 1μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic st...

YN321015 8-Hydroxy-DPAT hydrobromi... 76135-31-4

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective5-HT1Aagonist with apIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1binding site...