YN320879 Ziprasidone 146939-27-7

Ziprasidone, an antipsychotic agent, is a combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone has high affinity for rat (Ki: 3.4nM)/human (2.5nM) 5-HT1A receptors, 5-HT2A (0.42nM), and dopamine D2 receptor...

YN320660 Talsaclidine 147025-53-4

Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at theM1subtype, and as a partial agonist at theM2 and M3 subtypes.

YN320054 Maropitant 147116-67-4

Maropitant is a selective and orally activeneurokinin (NK1) receptorantagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly ef...

YN372287 Ranirestat 147254-64-6

Ranirestat (AS-3201) potent and orally activealdose reductase (AR)inhibitor with IC50s of 11nM and 15nM forrat lens AR and recombinant human AR, respectively, and a Ki of 0.38nM forrecombinant human AR. Ranirestat ha...

YN320170 MHP 133 147340-43-0

MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Kiof 69μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

YN360154 ABT-418 hydrochloride 147388-83-8

ABT-418 hydrochloride is a potent and selective agonist ofnAChRswith cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

YN321678 Telenzepine dihydrochloride 147416-96-4

Telenzepine dihydrochloride is a selective and orally activemuscarinic M1 receptorantagonist with a Ki of 0.94nM. Telenzepine dihydrochloride inhibits gastric acid secretion and has antiulcer effects .

YN484113 Peripheral Myelin P0 Prote... 147450-30-4

Peripheral Myelin P0 Protein (180-199), mouse, a neuritogenic peptide, is a purified component of murine peripheral nerve myelin.

YN484208 Pyridazinediones-derivative-1 147493-44-5

Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows anED50of 2.1μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.

YN380304 β-Amyloid (1-9) 147529-30-4

β-Amyloid (1-9), an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid (1-9) contains a B cell epitope, but it does not include T cell epitopes. Omission of residues 1 to 9 from the full-length A...

YN320132 DCG-IV 147782-19-2

DCG-IV is a potent agonist of group IImGluRswith EC50s of 0.35 and 0.09μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630μM) and III rec...

YN361021 ω-Conotoxin MVIIC 147794-23-8

ω-Conotoxin MVIIC is a N- and P/Q-typeCa2+channelblocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

YN370036 CA-074 methyl ester 147859-80-1

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.

YN373643 Calcineurin autoinhibitory pe... 148067-21-4

Calcineurin autoinhibitory peptide is a selective inhibitor ofCa2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death...

YN483966 N-Boc-Phe-Leu-Phe-Leu-P... 148182-34-7

N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is aformyl peptide receptor 1 (FPR1)antagonist, which increases pain effects and inhibits antinociceptive activity of annexin.

YN484023 β-Amyloid (13-27) 148270-13-7

β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.

YN270626 Prion Protein 106-126 (human... 148439-49-0

Prion Protein 106-126 (human), a peptide fragment of prion, and can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform ...

YN320117 L-732138 148451-96-1

L-732138 (L-732,138) is a selective, potent and competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibits the binding of ¹²⁵I-SP to the human NK-1 receptor stably expr...

YN321806 Substance P TFA 148470-19-3

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P isneurokinin 1 receptor(NK1-receptor,NK1R).

YN320549 GR 125743 148547-33-5

GR 125743 is a selective5-HT1B/1Dreceptor antagonist, with aKdof 0.61nM for h5-HT1B. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases.