YN320861 L-733060 hydrochloride 148687-76-7

L-733060 hydrochloride is a potent tachykininNK1receptorantagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral a...

YN481203 RP 48497 148891-53-6

RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine sedative-hypnotic used in the treatment of insomnia.

YN340187 AG-825 149092-50-2

AG-825 (Tyrphostin AG-825) is a selective and ATP-competitiveErbB2inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35μM. AG-825 displays anti-cancer activity . AG825 significantly accelerates apop...

YN483950 Secretoneurin, rat 149146-12-3

Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat induces dopamine release in the rat striatum in vivo and in vitro, and it exerts a very strong...

YN380297 β-Amyloid (31-35) 149385-65-9

β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

YN483695 D-Tetramannuronic acid 149511-34-2

D-Tetramannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Tetramannuronic acid can be used for the research of pain and vascular dementia.

YN483852 Myelin Oligodendrocyte Glyc... 149635-73-4

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensiv...

YN372462 Sacubitrilat 149709-44-4

Sacubitrilat (Sac, LBQ-657) is an active inhibitor of neprilysin (NEP).

YN320043 (S)-MCPG 150145-89-4

(S)-MCPG ((+)-MCPG) is a potentgroup I/II metabotropic glutamate receptor (mGluRs)antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spa...

YN321779 Strictosidinic acid 150148-81-5

Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated fromPsychotria myrianthaleaves, inhibits precursor enzymes of5-HTbiosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral anal...

YN321866 BIM-23056 150155-61-6

BIM 23056, a linear octapeptide, is a potentsst3 and sst5somatostatin receptor antagonist with Ki values of 10.8, 5.7, respectively.

YN483989 Proadrenomedullin (1-20), hum... 150238-87-2

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a nonco...

YN360086 NS-638 150493-34-8

NS-638 is a small nonpeptide molecule withCa2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4μM.

YN360836 Nitenpyram 150824-47-8

Nitenpyram is a calss of neonicotinoid and an insectnicotinic acetylcholine receptor (nAChR)agonist with an IC50 of 14nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals.

YN321568 Perospirone 150915-41-6

Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.

YN1730094 Bupropion D9 150988-80-0

Bupropion D9 is a deuterium labeled Bupropion. Bupropion is an atypical antidepressant of the aminoketone group and inhibits dopamine, norepinephrine reuptake and blocks several nicotinic receptors.

YN320012 AP521 151227-08-6

AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94nM.

YN360125 S-8510 phosphate 151466-23-8

S-8510 (phosphate) is an inverseBenzodiazepine (BDZ) receptoragonist, with Kis of 34.6nM, 36.2nM for –GABA and +GABA respectively.

YN440018 Rp-cAMPS triethylammonium... 151837-09-1

Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependentPKA I and II(Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS triethylammonium s...

YN350025 SB 202190 152121-30-7

SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo.