YN320412 Risperidone hydrochloride 666179-74-4

Risperidone hydrochloride (R 64 766 hydrochloride)5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamine D2receptorantagonist, with Kisof 4.8, 5.9nM for 5-HT2A and dopamine D2receptor, respectively.

YN320413 Risperidone mesylate 666179-96-0

Risperidone mesylate(R 64 766 mesylate) is a serotonin5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamine D2receptorantagonist, with Kisof 4.8, 5.9nM for 5-HT2A and dopamine D2receptor, respectively.

YN320351 Facinicline hydrochloride 677305-02-1

Facinicline hydrochloride (RG3487 hydrochloride) is an orally activenicotinic α7 receptorpartial agonist, with a Ki of 6nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimot...

YN320888 Pimavanserin 706779-91-1

Pimavanserin is a selective inverse agonist of the5-HT2Areceptor withpIC50 and pKdof 8.73 and 9.3, respectively.

YN320889 Pimavanserin tartrate 706782-28-7

Pimavanserin is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.

YN320455 Syk Inhibitor II 726695-51-8

Syk Inhibitor II is a potent, high selective and ATP-competitiveSykinhibitor with an IC50 of 41nM. Syk Inhibitor II inhibits5-HTrelease from RBL-cells with an IC50 of 460nM. Syk Inhibitor II shows less potent ag...

YN320878 Olanzapine D3 786686-79-1

Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is a selective monoaminergic antagonist with high affinity binding toserotonin H1, 5HT2A/2C, 5HT3, 5HT6(Ki=7, 4, 11, 57, and 5nM, respectively),...

YN320906 Cariprazine 839712-12-8

Cariprazine is a novel antipsychotic drug c and idate that exhibits high affinity for theD3(Ki=0.085nM) and D2(Ki=0.49nM) receptors, and moderate affinity for the5-HT1Areceptor (Ki=2.6nM).

YN320287 Nelotanserin 839713-36-9

Nelotanserin is a potent5-HT2Ainverse agonist, a moderately potent5-HT2Cpartial inverse agonist and a weak5-HT2Binverse agonist, with IC50s of 1.7, 79, 791nM in IP accumulation assays, respectively.

YN320857 GSK163090 844903-58-8

GSK163090 is a potent, selective and orally active5-HT1A/1B/1Dreceptorantagonist with pKi values. of 9.4/8.5/9.7, respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter (SerT) with apKiva...

YN321217 2-Methyl-5-HT hydrochloride 845861-49-6

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective5-HT3receptoragonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.

YN321255 JNJ-18038683 851376-05-1

JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, withpKisof 8.19, 8.20 for rat and human 5-HT7in HEK293 cells, respectively.

YN320994 PRX-08066 866206-54-4

PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4nM) antagonist that causes selective vasodilation of pulmonary arteries.

YN321231 Isamoltane hemifumarate 874882-92-5

Isamoltane hemifumarate is a selective antagonist of5-HT1Breceptor, with an IC50 of 39nM for inhibits the binding of [125I]ICYP to 5-HT1Brecognition sites in rat brain membranes. Isamoltane hemifumarate is also aβ-adrenocep...

YN321573 Dolasetron Mesylate hydrate 878143-33-0

Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

YN320067 Keto Ziprasidone 884305-07-1

Keto Ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

YN320068 Hydroxy ziprasidone 884305-08-2

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

YN320431 Vabicaserin hydrochloride 887258-94-8

Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C)receptor-selective agonist with an EC50 of 8nM.

YN320288 Temanogrel 887936-68-7

Temanogrel is a highly selective5-HT2Areceptorantagonist with a Ki of 4.9nM.

YN321225 SB-616234-A 908601-49-0

SB-616234-A is a selective and orally bioavailable5-HT1B receptorantagonist, with anxiolytic and antidepressant activity.