YN371731 GS-704277 1911579-04-8

GS-704277 is an alanine metabolite of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

YN250322 DDX3-IN-1 1919828-83-3

DDX3-IN-1 (Compound 16f) is a DEAD-box polypeptide 3 (DDX3) inhibitor withCC50s of 50 and 36μM forHIV and HCV, respectively. Antiviral activity.

YN370862 PC945 1931946-73-4

PC945, a potent, long-actingantifungaltriazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains ofAspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor ofA. fumigatus...

YN250317 BKI-1369 1951431-22-3

BKI-1369 is abumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52μM. BKI-1369 reduces the parasite burden and diseases severity in the gnoto...

YN250376 MDRTB-IN-1 1973401-05-6

MDRTB-IN-1 (5aα) is an antibiotic which is againstMycobacterium tuberculosisH37Rv with aMIC90value of 10.5μM.

YN330097 Selgantolimod 2004677-13-6

Selgantolimod (GS-9688) is an orally active, potent and selectivetoll-like receptor 8 (TLR8)agonist for the treatment ofhepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection .

YN250441 Propargyl-PEG8-acid 2055014-94-1

Propargyl-PEG8-acid is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria.

YN290125 IMP-1088 2059148-82-0

IMP-1088 is a potenthuman N-myristoyltransferasesnMT1 and NMT2dual inhibitor with IC50s of <1nM for HsNMT1 and HsNMT2. IMP-1088 has aKdof <210 pM for HsNMT1. IMP-1088 efficiently blocksrhinovirus replicatio...

YN250569 Atovaquone D4 2070015-14-2

Atovaquone D4 is the deuterium labeled Atovaquone. Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

YN250269 RG7834 2072057-17-9

RG7834 (RO 7020322) is a highly selective and orally bioavailableHBVinhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2nM, respectively, in dHepaRG...

YN250283 Fosmanogepix 2091769-17-2

Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrumantifungalagent, which targets the highly conservedGwt1fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and c...

YN290111 3'-Azido-3'-deoxy-5-fluorocyt... 2095417-18-6

3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.

YN251428 Sofosbuvir impurity M 2095551-10-1

Sofosbuvir impurity M, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor ofHCVRNA replication, demonstrates potent anti-hepatitis C virus activity.

YN250450 Isatropolone A 2097813-40-4

Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated fromStreptomyces Gö66. Isatropolone A shows potent activity againstLeishmania donovaniwith an IC50 of 0.5μM.

YN250296 R-10015 2097938-51-5

R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.

YN250546 Tenofovir diphosphate triethy... 2122333-63-3

Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitiveDNA polymerasesinhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1)reverse transcriptase(RT).

YN250148 GSK656 2131798-13-3

GSK656 is a potent antitubercular agent, acting as an inhibitor ofMycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2μM.

YN250348 GLP-26 2133017-36-2

GLP-26 is aHBVcapsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3nM), and reduces cccDNA by >90% at 1μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nu...

YN250208 ABBV-744 2138861-99-9

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.

YN270127 HS-1371 2158197-70-5

HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.