BI-882370
Cat. No. :YN350054
CAS No. :1392429-79-6
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order@ubiochem.com| Product Name: | BI-882370 |
| CAS NO.: | 1392429-79-6 |
| Chemical Name: | |
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| Molecular Weight: | 569.67 |
| Molecular Formula: | C₂₈H₃₃F₂N₇O₂S |
| SMILES: | CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | BI-882370 is a potent and selectiveRAFkinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6nM, respectively. BI-882370 also inhibits SRC family kinases. |
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