Avapritinib
Cat. No. :YN440036
CAS No. :1703793-34-3
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order@ubiochem.com| Product Name: | Avapritinib |
| CAS NO.: | 1703793-34-3 |
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| Molecular Weight: | 498.56 |
| Molecular Formula: | C₂₆H₂₇FN₁₀ |
| SMILES: | CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Avapritinib (BLU-285) is a highly potent, selective, and orally activeKIT and PDGFRAactivation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24nM forKIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2. |
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