c-Kit-IN-3
Cat. No. :YN440227
CAS No. :2363169-01-9
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order@ubiochem.com| Product Name: | c-Kit-IN-3 |
| CAS NO.: | 2363169-01-9 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 516.90 |
| Molecular Formula: | C₂₆H₂₀ClF₃N₂O₄ |
| SMILES: | O=C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1)CC4=CC=C(Cl)C(C(F)(F)F)=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | c-Kit-IN-3 (Compound 18) is a potent and selectivec-KIT kinaseinhibitor with anIC50s of 4nM, 8nM for c-KIT wt and c-KIT T670I, respectively. c-Kit-IN-3 displays great potencies against most of the gain-offunction mutations in the juxtamembrane domain, drugresistant mutations in the ATP binding pocket, and activation loops. |
| IC50&Target: | |
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